Deletion of PTENP1 pseudogene in human melanoma
نویسندگان
چکیده
1. Poliseno, L., et al., Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Ernst, A., et al., De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Dikstein, miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics. PLoS One. 5(5): p. e10859. 8. Liu, L., et al., miR-22 functions as a micro-oncogene in transformed human bronchial epithelial cells induced by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
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Decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with HNSCC
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Phosphatase and tensin homolog (PTEN) is a tumor-suppressor gene. PTEN pseudogene (PTENp) acts as an endogenous RNA, which regulates its parental gene by competitively binding to the 3' UTR of PTEN gene in the human. Despite the importance of this pseudogene, little is known about the molecular evolution of PTENp in mammals. In this study, we identified 37 pseudogenes from 65 mammalian genomes....
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عنوان ژورنال:
دوره 131 شماره
صفحات -
تاریخ انتشار 2011